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Home - Products - Cell Cycle/DNA Damage - DNA Repair Protein - NSC 19630

NSC 19630

CAS No. 72835-26-8

NSC 19630( MIRA-1 )

Catalog No. M15787 CAS No. 72835-26-8

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 19630
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
  • Description
    NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM; shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB); dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells; delays S-phase progression and induces DNA damage; a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.
  • In Vitro
    Cell Proliferation Assay Cell Line:Saos-2-His273, H1299-His175, SKOV-His175 and SKOV-His273 Concentration:25 μM Incubation Time:48 hours Result:Inhibited cell growth in a mutant p53-dependent manner, with survival rate of 18.5~39% in no doxycycline and 71.5~87.5% in doxycycline.Apoptosis Analysis Cell Line:Saos-2 and Saos-2-His273 cells Concentration:10 μM Incubation Time:48 hours Result:Caused a substantial increase in the fraction of cells with a sub-G1 DNA content in the presence of mutant p53.
  • In Vivo
    ——
  • Synonyms
    MIRA-1
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Repair Protein
  • Recptor
    DNA Repair Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72835-26-8
  • Formula Weight
    183.2
  • Molecular Formula
    C8H9NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (545.97 mM)
  • SMILES
    O=C(C=C1)N(COC(CC)=O)C1=O
  • Chemical Name
    1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. 2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31. 3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.
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